A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

The farnesyltransferase inhibitor L-744,832 selectively blocks the transformed phenotype of cultured cells expressing a mutated H-ras gene and induces dramatic regression of mammary and salivary carcinomas in mouse mammary tumor virus (MMTV)–v-Ha-ras transgenic mice. To better understand how the far...

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Main Authors: Barrington, Rebecca E., Subler, Mark A., Rands, Elaine, Omer, Charles A., Miller, Patricia J., Hundley, Jeffrey E., Koester, Steven K., Troyer, Dean A., Bearss, David J., Conner, Michael W., Gibbs, Jackson B., Hamilton, Kelly, Koblan, Kenneth S., Mosser, Scott D., O’Neill, Timothy J., Schaber, Michael D., Senderak, Edith T., Windle, Jolene J., Oliff, Allen, Kohl, Nancy E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC121456/
https://ncbi.nlm.nih.gov/pubmed/9418856
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