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Resuscitating Mutations in a Furin Cleavage-Deficient Mutant of the Flavivirus Tick-Borne Encephalitis Virus

Cleavage of the viral surface protein prM by the proprotein convertase furin is a key step in the maturation process of flavivirus particles. A mutant of tick-borne encephalitis virus (TBEV) carrying a deletion mutation within the furin recognition motif of protein prM (changing R-T-R-R to R-T-R) wa...

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Autors principals: Elshuber, Sigrid, Mandl, Christian W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1212607/
https://ncbi.nlm.nih.gov/pubmed/16140758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.18.11813-11823.2005
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