Proteolytic activation of tick-borne encephalitis virus by furin.

Flaviviruses are assembled intracellularly in an immature form containing heterodimers of two envelope proteins, E and prM. Shortly before the virion exits the cell, prM is cleaved by a cellular enzyme, and this processing step can be blocked by treatment with agents that raise the pH of exocytic co...

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Bibliographic Details
Main Authors: Stadler, K, Allison, S L, Schalich, J, Heinz, F X
Format: Artigo
Language:Inglês
Published: 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC192310/
https://ncbi.nlm.nih.gov/pubmed/9343204
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