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Changing the Protease Specificity for Activation of a Flavivirus, Tick-Borne Encephalitis Virus
The infectivity of flavivirus particles depends on a maturation process that is triggered by the proteolytic cleavage of the precursor of the M protein (prM). This activation cleavage is naturally performed by ubiquitous cellular proteases of the furin family, which typically recognize the multibasi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519671/ https://ncbi.nlm.nih.gov/pubmed/18562534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00587-08 |
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