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Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

Multiple sclerosis is mediated by T-cell responses to central nervous system antigens such as myelin basic protein (MBP). To investigate self-peptide/major histocompatibility complex (MHC) recognition and T-cell receptor (TCR) degeneracy, we determined the crystal structure, at 2.8 Å resolution, of...

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Detaylı Bibliyografya
Asıl Yazarlar: Li, Yili, Huang, Yuping, Lue, Jessica, Quandt, Jacqueline A, Martin, Roland, Mariuzza, Roy A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201352/
https://ncbi.nlm.nih.gov/pubmed/16079912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600771
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