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Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope
The degradation of myelin in the CNS is the hallmark of multiple sclerosis. Reduction in the net positive charge of myelin basic protein (MBP), through deimination, correlates strongly with disease severity and may mediate myelin instability and loss of compaction. Using Cys scanning, spin labeling,...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450187/ https://ncbi.nlm.nih.gov/pubmed/16537438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509158103 |
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