Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis

Myelin basic protein (MBP) and its interaction with lipids of the myelin sheath plays an important part in the pathology of multiple sclerosis (MS). Previous studies observed that changes in the myelin lipid composition lead to instabilities and enhanced local curvature of MBP-lipid multilayer struc...

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Pubblicato in:Sci Rep
Autori principali: Krugmann, Benjamin, Radulescu, Aurel, Appavou, Marie-Sousai, Koutsioubas, Alexandros, Stingaciu, Laura R., Dulle, Martin, Förster, Stephan, Stadler, Andreas M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542173/
https://ncbi.nlm.nih.gov/pubmed/33028889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73671-3
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