Solid-State NMR Spectroscopy of Membrane-Associated Myelin Basic Protein—Conformation and Dynamics of an Immunodominant Epitope

Myelin basic protein (MBP) maintains the tight multilamellar compaction of the myelin sheath in the central nervous system through peripheral binding of adjacent lipid bilayers of oligodendrocytes. Myelin instability in multiple sclerosis (MS) is associated with the loss of positive charge in MBP as...

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Main Authors: Ahmed, Mumdooh A.M., Bamm, Vladimir V., Harauz, George, Ladizhansky, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
Assuntos:
Protein
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920716/
https://ncbi.nlm.nih.gov/pubmed/20713009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.022
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