A Toll-Like Receptor 2-Responsive Lipid Effector Pathway Protects Mammals against Skin Infections with Gram-Positive Bacteria

flake (flk), an N-ethyl-N-nitrosourea-induced recessive germ line mutation of C57BL/6 mice, impairs the clearance of skin infections by Streptococcus pyogenes and Staphylococcus aureus, gram-positive pathogens that elicit innate immune responses by activating Toll-like receptor 2 (TLR2) (K. Takeda a...

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Autores principales: Georgel, Philippe, Crozat, Karine, Lauth, Xavier, Makrantonaki, Evgenia, Seltmann, Holger, Sovath, Sosathya, Hoebe, Kasper, Du, Xin, Rutschmann, Sophie, Jiang, Zhengfan, Bigby, Timothy, Nizet, Victor, Zouboulis, Christos C., Beutler, Bruce
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Host Response and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201198/
https://ncbi.nlm.nih.gov/pubmed/16040962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.8.4512-4521.2005
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