Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc) and Lackadaisical were found to alter MyD88, creating striking receptor-selective effects. Poc, in particular, prevented sensing of all MyD88-dependent Toll-like receptor (TLR) ligands except diacyl lipopeptides. Furthermore...

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Detalhes bibliográficos
Main Authors: Jiang, Zhengfan, Georgel, Philippe, Li, Chenglong, Choe, Jungwoo, Crozat, Karine, Rutschmann, Sophie, Du, Xin, Bigby, Tim, Mudd, Suzanne, Sovath, Sosathya, Wilson, Ian A., Olson, Arthur, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544157/
https://ncbi.nlm.nih.gov/pubmed/16832055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603804103
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