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Mathematical Assumptions versus Biological Reality: Myths in Affected Sib Pair Linkage Analysis
Affected sib pair (ASP) analysis has become common ever since it was shown that, under very specific assumptions, ASPs afford a powerful design for linkage analysis. In 2003, Vieland and Huang, on the basis of a “fundamental heterogeneity equation,” proved that heterogeneity and epistasis are confou...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society of Human Genetics
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1196418/ https://ncbi.nlm.nih.gov/pubmed/15540158 |
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