Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance

Studies of early bactericidal activity provide a fast and economic way to evaluate the clinical efficacy of potential agents for the treatment of tuberculosis. Based on good early bactericidal activity data, ciprofloxacin entered further studies and is now recommended as part of treatment for multid...

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Hlavní autoři: Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Drusano, George L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196238/
https://ncbi.nlm.nih.gov/pubmed/16048921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3178-3181.2005
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