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Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin
Rifampin is a cornerstone of modern antituberculosis therapy. However, rifampin's half-life of 3 h is believed to limit its utility for intermittent therapy, so new congeners with long half-lives are being developed. Using an in vitro pharmacokinetic-pharmacodynamic model of tuberculosis, we ex...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151424/ https://ncbi.nlm.nih.gov/pubmed/17724157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01533-06 |
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