Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

Rifampin is a cornerstone of modern antituberculosis therapy. However, rifampin's half-life of 3 h is believed to limit its utility for intermittent therapy, so new congeners with long half-lives are being developed. Using an in vitro pharmacokinetic-pharmacodynamic model of tuberculosis, we ex...

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Bibliographic Details
Main Authors: Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Parsons, Linda M., Salfinger, Max, Drusano, George L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151424/
https://ncbi.nlm.nih.gov/pubmed/17724157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01533-06
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