Role of embB Codon 306 Mutations in Mycobacterium tuberculosis Revisited: a Novel Association with Broad Drug Resistance and IS6110 Clustering Rather than Ethambutol Resistance

Mutations at position 306 of embB (embB306) have been proposed as a marker for ethambutol resistance in Mycobacterium tuberculosis; however, recent reports of embB306 mutations in ethambutol-susceptible isolates caused us to question the biological role of this mutation. We tested 1,020 clinical M....

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Auteurs principaux: Hazbón, Manzour Hernando, Bobadilla del Valle, Miriam, Guerrero, Marta Inírida, Varma-Basil, Mandira, Filliol, Ingrid, Cavatore, Magali, Colangeli, Roberto, Safi, Hassan, Billman-Jacobe, Helen, Lavender, Caroline, Fyfe, Janet, García-García, Lourdes, Davidow, Amy, Brimacombe, Michael, León, Clara Inés, Porras, Tania, Bose, Mridula, Chaves, Fernando, Eisenach, Kathleen D., Sifuentes-Osornio, José, Ponce de León, Alfredo, Cave, M. Donald, Alland, David
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195424/
https://ncbi.nlm.nih.gov/pubmed/16127055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3794-3802.2005
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