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Protection from Anthrax Toxin-Mediated Killing of Macrophages by the Combined Effects of Furin Inhibitors and Chloroquine
Cell surface proteolytic processing of anthrax protective antigen by furin or other furin-related proteases is required for its oligomerization, endocytosis, and function as a translocon for anthrax lethal and edema factors. Countering toxin lethality is essential to developing effective chemotherap...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1195394/ https://ncbi.nlm.nih.gov/pubmed/16127065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3875-3882.2005 |
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