Protection from Anthrax Toxin-Mediated Killing of Macrophages by the Combined Effects of Furin Inhibitors and Chloroquine

Cell surface proteolytic processing of anthrax protective antigen by furin or other furin-related proteases is required for its oligomerization, endocytosis, and function as a translocon for anthrax lethal and edema factors. Countering toxin lethality is essential to developing effective chemotherap...

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Bibliographic Details
Main Authors: Komiyama, Tomoko, Swanson, Joel A., Fuller, Robert S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195394/
https://ncbi.nlm.nih.gov/pubmed/16127065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3875-3882.2005
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