Proteasome Activity Is Required for Anthrax Lethal Toxin To Kill Macrophages

Anthrax lethal toxin (LeTx), consisting of protective antigen (PA) and lethal factor (LF), rapidly kills primary mouse macrophages and macrophage-like cell lines such as RAW 264.7. LF is translocated by PA into the cytosol of target cells, where it acts as a metalloprotease to cleave mitogen-activat...

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Pubblicato in:	Infect Immun
Autori principali:	Tang, Guangqing, Leppla, Stephen H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10338520/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.6.3055-3060.1999
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