Enhanced NF-κB activation and cellular function in macrophages lacking IκB kinase 1 (IKK1)

IκB kinase (IKK) complex plays a key regulatory role in macrophages for NF-κB activation during both innate and adaptive immune responses. Because IKK1(–/–) mice died at birth, we differentiated functional macrophages from embryonic day 15.5 IKK1 mutant embryonic liver. The embryonic liver-derived m...

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Detalles Bibliográficos
Main Authors: Li, Qiutang, Lu, Qingxian, Bottero, Virginie, Estepa, Gabriela, Morrison, Lisa, Mercurio, Frank, Verma, Inder M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1194954/
https://ncbi.nlm.nih.gov/pubmed/16116086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505997102
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