Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation

BACKGROUND: The active copy of the imprinted gene H19 is turned off by inappropriate methylation in several pediatric tumors including Wilms' Tumour and embryonal rhabdomyosarcoma. H19 controls in cis the linked Insulin-like Growth Factor 2 (IGF2) gene, encoding an important growth factor. Rece...

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Autori principali: Lynch, Catherine A, Tycko, Benjamin, Bestor, Timothy H, Walsh, Colum P
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2002
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC119368/
https://ncbi.nlm.nih.gov/pubmed/12234381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-1-2
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