dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

Transcription regulation involves enzyme-mediated changes in chromatin structure. Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2). This pathway was uncovered thr...

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Autors principals: Lagarou, Anna, Mohd-Sarip, Adone, Moshkin, Yuri M., Chalkley, Gillian E., Bezstarosti, Karel, Demmers, Jeroen A.A., Verrijzer, C. Peter
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569881/
https://ncbi.nlm.nih.gov/pubmed/18923078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.484208
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