PGE2 induces interleukin-8 derepression in human astrocytoma through coordinated DNA demethylation and histone hyperacetylation

We have recently reported that in astrocytoma cells the expression of interleukin-8 (IL-8) is upregulated by prostaglandin E2 (PGE2). Unfortunately, the exact mechanism by which this happens has not been clarified yet. Here, we have investigated whether IL-8 activation by PGE2 involves changes in DN...

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Detalhes bibliográficos
Main Authors: Venza, Isabella, Visalli, Maria, Fortunato, Cinzia, Ruggeri, Manuela, Ratone, Simona, Caffo, Maria, Caruso, Gerardo, Alafaci, Concetta, Tomasello, Francesco, Teti, Diana, Venza, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499332/
https://ncbi.nlm.nih.gov/pubmed/23051921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.22446
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