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Histone H3 K56 Hyperacetylation Perturbs Replisomes and Causes DNA Damage
Deacetylation of histone H3 K56, regulated by the sirtuins Hst3p and Hst4p, is critical for maintenance of genomic stability. However, the physiological consequences of a lack of H3 K56 deacetylation are poorly understood. Here we show that cells lacking Hst3p and Hst4p, in which H3 K56 is constitut...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516057/ https://ncbi.nlm.nih.gov/pubmed/18579506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.088914 |
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