A Capsid-Modified Helper-Dependent Adenovirus Vector Containing the β-Globin Locus Control Region Displays a Nonrandom Integration Pattern and Allows Stable, Erythroid-Specific Gene Expression

Gene therapy for hemoglobinopathies requires efficient gene transfer into hematopoietic stem cells and high-level erythroid-specific gene expression. Toward this goal, we constructed a helper-dependent adenovirus vector carrying the β-globin locus control region (LCR) to drive green fluorescent prot...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Wang, Hongjie, Shayakhmetov, Dmitry M., Leege, Tobias, Harkey, Michael, Li, Qiliang, Papayannopoulou, Thalia, Stamatoyannopolous, George, Lieber, André
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Gene Delivery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193620/
https://ncbi.nlm.nih.gov/pubmed/16103151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.10999-11013.2005
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares