A Capsid-Modified Helper-Dependent Adenovirus Vector Containing the β-Globin Locus Control Region Displays a Nonrandom Integration Pattern and Allows Stable, Erythroid-Specific Gene Expression

Gene therapy for hemoglobinopathies requires efficient gene transfer into hematopoietic stem cells and high-level erythroid-specific gene expression. Toward this goal, we constructed a helper-dependent adenovirus vector carrying the β-globin locus control region (LCR) to drive green fluorescent prot...

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Autores principales: Wang, Hongjie, Shayakhmetov, Dmitry M., Leege, Tobias, Harkey, Michael, Li, Qiliang, Papayannopoulou, Thalia, Stamatoyannopolous, George, Lieber, André
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Gene Delivery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193620/
https://ncbi.nlm.nih.gov/pubmed/16103151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.10999-11013.2005
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