Hepatitis A Virus Suppresses RIG-I-Mediated IRF-3 Activation To Block Induction of Beta Interferon

Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of double-stranded RNA (dsRNA)-induced beta interferon (IFN-β) gene expression. In this report, we show that this is due to an interaction of HAV with the intracellular dsRNA-induced retinoic acid-inducible gene I (RIG-I)-m...

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Bibliographische Detailangaben
Hauptverfasser: Fensterl, Volker, Grotheer, Dajana, Berk, Iris, Schlemminger, Stefanie, Vallbracht, Angelika, Dotzauer, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Cellular Response to Infection
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193608/
https://ncbi.nlm.nih.gov/pubmed/16103148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.10968-10977.2005
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