Hantavirus GnT Elements Mediate TRAF3 Binding and Inhibit RIG-I/TBK1-Directed Beta Interferon Transcription by Blocking IRF3 Phosphorylation

Hantaviruses successfully replicate in primary human endothelial cells by restricting the early induction of beta interferon (IFN-β) and interferon-stimulated genes (ISGs). Gn proteins from NY-1V, ANDV, and TULV, but not PHV, harbor elements in their 142-residue cytoplasmic tails (GnTs) that inhibit...

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Autori principali: Matthys, Valery S., Cimica, Velasco, Dalrymple, Nadine A., Glennon, Nicole B., Bianco, Chris, Mackow, Erich R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911538/
https://ncbi.nlm.nih.gov/pubmed/24390324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02647-13
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