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The NY-1 Hantavirus Gn Cytoplasmic Tail Coprecipitates TRAF3 and Inhibits Cellular Interferon Responses by Disrupting TBK1-TRAF3 Complex Formation

Pathogenic hantaviruses replicate within human endothelial cells and cause two diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. In order to replicate in endothelial cells pathogenic hantaviruses inhibit the early induction of beta interferon (IFN-β). Expression of t...

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Main Authors: Alff, Peter J., Sen, Nandini, Gorbunova, Elena, Gavrilovskaya, Irina N., Mackow, Erich R.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546897/
https://ncbi.nlm.nih.gov/pubmed/18614628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00290-08
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