Repression of c-Kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation

Stem cell factor (SCF), erythropoietin (Epo), and GATA-1 play an essential role(s) in erythroid development. We examined how these proteins interact functionally in G1E cells, a GATA-1(−) erythroblast line that proliferates in an SCF-dependent fashion and, upon restoration of GATA-1 function, underg...

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Detalhes bibliográficos
Main Authors: Munugalavadla, Veerendra, Dore, Louis C., Tan, Bai Lin, Hong, Li, Vishnu, Melanie, Weiss, Mitchell J., Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190349/
https://ncbi.nlm.nih.gov/pubmed/16024808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6747-6759.2005
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