Disruption of Mechanisms That Prevent Rereplication Triggers a DNA Damage Response

Eukaryotes replicate DNA once and only once per cell cycle due to multiple, partially overlapping mechanisms efficiently preventing reinitiation. The consequences of reinitiation are unknown. Here we show that the induction of rereplication by mutations in components of the prereplicative complex (o...

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Bibliografiske detaljer
Main Authors: Archambault, Vincent, Ikui, Amy E., Drapkin, Benjamin J., Cross, Frederick R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Chromosome Structure and Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190345/
https://ncbi.nlm.nih.gov/pubmed/16024805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6707-6721.2005
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