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Disruption of Mechanisms That Prevent Rereplication Triggers a DNA Damage Response

Eukaryotes replicate DNA once and only once per cell cycle due to multiple, partially overlapping mechanisms efficiently preventing reinitiation. The consequences of reinitiation are unknown. Here we show that the induction of rereplication by mutations in components of the prereplicative complex (o...

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Detalhes bibliográficos
Main Authors: Archambault, Vincent, Ikui, Amy E., Drapkin, Benjamin J., Cross, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190345/
https://ncbi.nlm.nih.gov/pubmed/16024805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6707-6721.2005
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