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Cyclin and Cyclin-Dependent Kinase Substrate Requirements for Preventing Rereplication Reveal the Need for Concomitant Activation and Inhibition
DNA replication initiation in S. cerevisiae is promoted by B-type cyclin-dependent kinase (Cdk) activity. In addition, once-per-cell-cycle replication is enforced by cyclin-Cdk-dependent phosphorylation of the prereplicative complex (pre-RC) components Mcm2-7, Cdc6, and Orc1-6. Several of these cont...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Copyright © 2007 by the Genetics Society of America
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1840059/ https://ncbi.nlm.nih.gov/pubmed/17194775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.068213 |
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