A Mutation in Dbf4 Motif M Impairs Interactions with DNA Replication Factors and Confers Increased Resistance to Genotoxic Agents

Dbf4/Cdc7 is required for DNA replication in Saccharomyces cerevisiae and appears to be a target in the S-phase checkpoint. Previously, a 186-amino-acid Dbf4 region that mediates interactions with both the origin recognition complex and Rad53 was identified. We now show this domain also mediates the...

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Detalhes bibliográficos
Main Authors: Varrin, Angela E., Prasad, Ajai A., Scholz, Rolf-Peter, Ramer, Matthew D., Duncker, Bernard P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190303/
https://ncbi.nlm.nih.gov/pubmed/16107698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7494-7504.2005
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