Cationic Sites on Granzyme B Contribute to Cytotoxicity by Promoting Its Uptake into Target Cells

Granzyme B (GrB) is a key effector of cytotoxic lymphocyte-mediated cell death. It is delivered to target cells bound to the proteoglycan serglycin, but how it crosses the plasma membrane and accesses substrates in the cytoplasm is poorly understood. Here we identify two cationic sequences on GrB th...

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Bibliographic Details
Main Authors: Bird, Catherina H., Sun, Jiuru, Ung, Kheng, Karambalis, Diana, Whisstock, James C., Trapani, Joseph A., Bird, Phillip I.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190293/
https://ncbi.nlm.nih.gov/pubmed/16107729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7854-7867.2005
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