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Cationic Sites on Granzyme B Contribute to Cytotoxicity by Promoting Its Uptake into Target Cells
Granzyme B (GrB) is a key effector of cytotoxic lymphocyte-mediated cell death. It is delivered to target cells bound to the proteoglycan serglycin, but how it crosses the plasma membrane and accesses substrates in the cytoplasm is poorly understood. Here we identify two cationic sequences on GrB th...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1190293/ https://ncbi.nlm.nih.gov/pubmed/16107729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7854-7867.2005 |
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