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Direct NMR observation of a substrate protein bound to the chaperonin GroEL

The reaction cycle and the major structural states of the molecular chaperone GroEL and its cochaperone, GroES, are well characterized. In contrast, very little is known about the nonnative states of the substrate polypeptide acted on by the chaperonin machinery. In this study, we investigated the s...

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Main Authors: Horst, Reto, Bertelsen, Eric B., Fiaux, Jocelyne, Wider, Gerhard, Horwich, Arthur L., Wüthrich, Kurt
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1188259/
https://ncbi.nlm.nih.gov/pubmed/16116078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505642102
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