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7-Deaza-2`-deoxyguanosine allows PCR and sequencing reactions from CpG islands
CpG islands are GC rich sequences that are found in the promoters of many genes in higher eukaryotes. They contain a high frequency of CG dinucleotides, which are substrates for DNA methylases. Methylation leads to transcriptional silencing of promoters. Owing to their high GC content CpG islands ex...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
British Medical Journal Publishing Group
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1187147/ https://ncbi.nlm.nih.gov/pubmed/11836448 |
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