7-Deaza-2`-deoxyguanosine allows PCR and sequencing reactions from CpG islands

CpG islands are GC rich sequences that are found in the promoters of many genes in higher eukaryotes. They contain a high frequency of CG dinucleotides, which are substrates for DNA methylases. Methylation leads to transcriptional silencing of promoters. Owing to their high GC content CpG islands ex...

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Библиографические подробности
Главные авторы: Jung, A, Ruckert, S, Frank, P, Brabletz, T, Kirchner, T
Формат: Artigo
Язык:Inglês
Опубликовано: British Medical Journal Publishing Group 2002
Предметы:
Short Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187147/
https://ncbi.nlm.nih.gov/pubmed/11836448
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