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Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation
Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potential when unopposed by its endogenous inhibitor, HAI-1. Modest orthotopic overexpression of matriptase in t...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1186192/ https://ncbi.nlm.nih.gov/pubmed/16103220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1300705 |
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