Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that epithelial stem cell expression of the protease suff...

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Autores principales: Sales, Katiuchia Uzzun, Friis, Stine, Konkel, Joanne E., Godiksen, Sine, Hatakeyama, Marcia, Hansen, Karina K., Rogatto, Silvia Regina, Szabo, Roman, Vogel, Lotte K., Chen, Wanjun, Gutkind, J. Silvio, Bugge, Thomas H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112178/
https://ncbi.nlm.nih.gov/pubmed/24469043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.563
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