Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potential when unopposed by its endogenous inhibitor, HAI-1. Modest orthotopic overexpression of matriptase in t...

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Bibliographische Detailangaben
Hauptverfasser: List, Karin, Szabo, Roman, Molinolo, Alfredo, Sriuranpong, Virote, Redeye, Vivien, Murdock, Tricia, Burke, Beth, Nielsen, Boye S., Gutkind, J. Silvio, Bugge, Thomas H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2005
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186192/
https://ncbi.nlm.nih.gov/pubmed/16103220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1300705
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