Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface

Thyroid hormone (TH) action is mediated by TH receptors (TRs), which are members of the nuclear hormone receptor superfamily. In vitro studies have demonstrated that TR activity is regulated by interactions with corepressor and coactivator proteins (CoRs and CoAs, respectively). TH stimulation is th...

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Detalhes bibliográficos
Main Authors: Ortiga-Carvalho, Tania M., Shibusawa, Nobuyuki, Nikrodhanond, Amisra, Oliveira, Karen J., Machado, Danielle S., Liao, Xiao-Hui, Cohen, Ronald N., Refetoff, Samuel, Wondisford, Fredric E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184039/
https://ncbi.nlm.nih.gov/pubmed/16100573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24109
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