Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations

A region-specific ENU mutagenesis screen was conducted to elucidate the functional content of proximal mouse Chr 5. We used the visibly marked, recessive, lethal inversion Rump White (Rw) as a balancer in a three-generation breeding scheme to identify recessive mutations within the ∼50 megabases spa...

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Bibliografski detalji
Glavni autori: Wilson, Lawriston, Ching, Yung-Hao, Farias, Michael, Hartford, Suzanne A., Howell, Gareth, Shao, Hongguang, Bucan, Maja, Schimenti, John C.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Letters
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182222/
https://ncbi.nlm.nih.gov/pubmed/16024820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.3826505
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