Thromboxane A(2)-induced contraction of rat caudal arterial smooth muscle involves activation of Ca(2+) entry and Ca(2+) sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697

The signal transduction pathway whereby the TxA(2) (thromboxane A(2)) mimetic U-46619 activates vascular smooth muscle contraction was investigated in de-endothelialized rat caudal artery. U-46619-evoked contraction was inhibited by the TP receptor (TxA(2) receptor) antagonist SQ-29548, the ROK (Rho...

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Detalhes bibliográficos
Main Authors: Wilson, David P., Susnjar, Marija, Kiss, Enikő, Sutherland, Cindy, Walsh, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180727/
https://ncbi.nlm.nih.gov/pubmed/15823093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050237
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