Inhibition of Rho-associated kinase blocks agonist-induced Ca(2+) sensitization of myosin phosphorylation and force in guinea-pig ileum

1. Ca(2+) sensitization of smooth muscle contraction involves the small GTPase RhoA, inhibition of myosin light chain phosphatase (MLCP) and enhanced myosin regulatory light chain (LC(20)) phosphorylation. A potential effector of RhoA is Rho-associated kinase (ROK). 2. The role of ROK in Ca(2+) sens...

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Detalhes bibliográficos
Main Authors: Swärd, Karl, Dreja, Karl, Susnjar, Marija, Hellstrand, Per, Hartshorne, David J, Walsh, Michael P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269742/
https://ncbi.nlm.nih.gov/pubmed/10618150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.0033m.x
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