טוען...
Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho
We have generated a line of mutant mouse that lacks βKlotho, a protein that structurally resembles Klotho. The synthesis and excretion of bile acids were found to be dramatically elevated in these mutants, and the expression of 2 key bile acid synthase genes, cholesterol 7α-hydroxylase (Cyp7a1) and...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Clinical Investigation
2005
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1180526/ https://ncbi.nlm.nih.gov/pubmed/16075061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI23076 |
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