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Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is essential for chromosome end-protection, as best demonstrated in fission yeast. In human cells, hPOT1 is also involved in telomere-length regulation. We now show that telo...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1180509/ https://ncbi.nlm.nih.gov/pubmed/16043710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504744102 |
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