Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells

Telomere extension by telomerase is essential for chromosome stability and cell vitality. Here, we report the identification of a splice variant of mammalian heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2), hnRNP A2*, which binds telomeric DNA and telomerase in vitro. hnRNP A2* colocalizes wit...

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Main Authors: Wang, Feng, Tang, Ming-liang, Zeng, Zhi-xiong, Wu, Ren-yi, Xue, Yong, Hao, Yu-hua, Pang, Dai-Wen, Zhao, Yong, Tan, Zheng
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528488/
https://ncbi.nlm.nih.gov/pubmed/23184978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200232109
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