Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase

The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models. The presumptive molecular target of this compound in E. tenella is cyclic...

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Veröffentlicht in:	Eukaryot Cell
Hauptverfasser:	Donald, Robert G. K., Allocco, John, Singh, Suresh B., Nare, Bakela, Salowe, Scott P., Wiltsie, Judyann, Liberator, Paul A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC118020/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12455981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/EC.1.3.317-328.2002
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