Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase

The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models. The presumptive molecular target of this compound in E. tenella is cyclic...

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Detalhes bibliográficos
Main Authors: Donald, Robert G. K., Allocco, John, Singh, Suresh B., Nare, Bakela, Salowe, Scott P., Wiltsie, Judyann, Liberator, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC118020/
https://ncbi.nlm.nih.gov/pubmed/12455981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.1.3.317-328.2002
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