Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase

The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) has in vivo activity against the apicomplexan parasites Toxoplasma gondii and Eimeria tenella in animal models. The presumptive molecular target of this compound in E. tenella is cyclic...

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Pubblicato in:	Eukaryot Cell
Autori principali:	Donald, Robert G. K., Allocco, John, Singh, Suresh B., Nare, Bakela, Salowe, Scott P., Wiltsie, Judyann, Liberator, Paul A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC118020/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12455981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/EC.1.3.317-328.2002
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