The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells

Stimulation of fibroblast growth factor receptor-1 (FGFR-1) is known to result in phosphorylation of tyrosine 766 and the recruitment and subsequent activation of phospholipase C-γ (PLC-γ). To assess the role of tyrosine 766 in endothelial cell function, we generated endothelial cells expressing a c...

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Hlavní autoři: Cross, Michael J., Lu, Lingge, Magnusson, Peetra, Nyqvist, Daniel, Holmqvist, Kristina, Welsh, Michael, Claesson-Welsh, Lena
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2002
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC117949/
https://ncbi.nlm.nih.gov/pubmed/12181353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-02-0103
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