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Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

Bruton's tyrosine kinase (Btk) acts downstream of phosphoinositide 3-kinase (PI3K) in a pathway required for B cell receptor (BCR)-dependent proliferation. We used DNA microarrays to determine what fraction of genes this pathway influences and to investigate whether PI3K and Btk mediate distinct gen...

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Wedi'i Gadw mewn:
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Fruman, David A., Ferl, Gregory Z., An, Sam S., Donahue, Amber C., Satterthwaite, Anne B., Witte, Owen N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2001
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117565/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756681/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012605099
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